Laurie's Blogs.

This blog is just a short little burst of random knowledge, sure to make your more interesting this week at work as you chat with clients and colleagues!  

It’s based on the following study:

Lee BT, Baker LA, Momen M, Terhaar H, Binversie EE, Sample SJ, Muir P. Identification of genetic variants associated with anterior cruciate ligament rupture and AKC standard coat color in the Labrador Retriever. BMC Genom Data. 2023 Oct 26;24(1):60. 

And here’s the short synopsis:

Cranial cruciate ligament (CCL) injuries are a common cause of lameness in dogs, particularly in breeds like Labrador Retrievers. Interestingly, recent research has uncovered a potential link between coat color and the risk of CCL rupture. Labrador Retrievers, which come in black, chocolate, and yellow, show different risks for this injury, with yellow Labs being more susceptible.

The study suggests that genetic factors linked to coat color might also influence the likelihood of CCL injuries. Specifically, the MC1R gene, which determines yellow coat color, is involved in inflammatory pathways that could predispose dogs to ligament issues. The researchers used a genome-wide association study (GWAS) to identify genes associated with both CCL injuries and coat color, focusing on a region of chromosome 5 near the MC1R gene. This region showed significant associations with CCL rupture, suggesting a complex interplay between genetic traits that influence both coat color and joint health.

Interestingly, the study also identified several other genes related to bone and cartilage health, inflammation, and gene regulation that may contribute to CCL rupture. These findings highlight the complex genetic landscape behind this common canine injury and open the door for further research into how coat color and other seemingly unrelated traits might influence health outcomes in dogs.

This groundbreaking study not only advances our understanding of CCL injuries in dogs but also provides valuable insights into the genetic factors that could help predict and prevent these injuries. As research continues, we may find more connections between seemingly unrelated traits and disease risk, ultimately improving the health and well-being of our canine companions.

And now your know!
Cheers,
Laurie